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[Phosphocreatine kinase activity in the cerebrospinal fluid in different types of stroke]
Insights
Cerebrospinal fluid creatine phosphokinase (CPK) activity significantly increases in patients experiencing brain strokes, including thrombosis, embolus, and hemorrhages. This elevation is most pronounced during the initial stroke phase as nervous tissue softens.
Area of Science:
- Neurology
- Biochemistry
Context:
- Cerebrospinal fluid (CSF) analysis is crucial for diagnosing neurological conditions.
- Brain strokes, encompassing ischemic and hemorrhagic types, represent a significant cause of mortality and morbidity.
- Creatine phosphokinase (CPK) is an enzyme released into circulation following muscle or brain tissue damage.
Purpose:
- To investigate the diagnostic utility of creatine phosphokinase (CPK) activity in cerebrospinal fluid (CSF) for patients with various types of brain strokes.
- To correlate CPK activity levels in CSF with the pathological progression of stroke.
Summary:
- CPK activity was measured in the CSF of 45 patients diagnosed with different types of brain strokes (thrombosis, embolus, intracerebral hemorrhages, subarachnoid hemorrhages).
- A significant elevation in CSF CPK activity was observed in the majority of stroke patients compared to a control group.
- In two cases, the dynamic changes in CSF CPK activity were monitored, suggesting a rise during the acute phase associated with nervous tissue softening.
Impact:
- This study highlights CSF CPK activity as a potential biomarker for early stroke detection and severity assessment.
- Findings may contribute to improved diagnostic strategies and understanding of stroke pathophysiology.
- Further research could explore the clinical application of CSF CPK measurements in stroke management.
Abstract:
In 45 patients with brain strokes (thrombosis, embolus, intracerebral haemorrhages) and subarachnoid haemorrhages the CPK activity was determined in the cerebrospinal fluid. In most cases a significant rise was observed in CPK activity in the cerebrospinal fluid as compared to the control group. In two cases the dynamics of CPK activity changes were studied in the cerebrospinal fluid during the stroke. It seems that a significant rise in CPK activity develops in the initial phase of the stroke when the area of nervous tissue softening develops and spreads.