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Cholesterol, high density lipoprotein and danazol

J K Allen, I S Fraser

    The Journal of Clinical Endocrinology and Metabolism
    |July 1, 1981
    PubMed
    Summary
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    Danazol treatment for endometriosis significantly lowers high-density lipoprotein cholesterol (HDL-C) levels. These lipid changes, including masked increases in other cholesterol types, reversed after discontinuing danazol.

    Area of Science:

    • Endocrinology
    • Lipid Metabolism
    • Pharmacology

    Background:

    • Danazol is a synthetic steroid widely prescribed for endometriosis.
    • Understanding danazol's impact on lipid profiles is crucial for patient management.

    Purpose of the Study:

    • To investigate the effects of danazol on plasma lipid levels, specifically high-density lipoprotein cholesterol (HDL-C).
    • To determine the reversibility of these lipid changes after danazol cessation.

    Main Methods:

    • A longitudinal study involving nine subjects undergoing a 6-month danazol treatment course.
    • Plasma lipid profiles (total cholesterol, HDL-C, triglycerides) and lipoprotein electrophoresis were analyzed during and after treatment.

    Main Results:

    Related Experiment Videos

  • Danazol significantly decreased plasma HDL-C levels (P < 0.001) during treatment.
  • Depressed HDL-C masked increases in other lipoprotein cholesterol fractions (P < 0.01).
  • Triglyceride levels remained unaffected; elevated beta-lipoprotein was observed.

    • Conclusions:

    • Danazol exerts significant, reversible effects on HDL-C and other lipoprotein levels.
    • Lipid profile normalization occurred within 3-5 months post-treatment cessation.