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Cutaneous extramedullary hematopoiesis presenting as leg ulcers
Journal of the American Academy of Dermatology
|May 1, 1981
Summary
Extramedullary hematopoiesis, a rare condition, can manifest as leg ulcers in myelofibrosis patients. This case highlights a novel clinical presentation, emphasizing the need for consideration in unusual skin eruptions.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Myelofibrosis is a bone marrow disorder characterized by fibrosis and extramedullary hematopoiesis.
- Cutaneous extramedullary hematopoiesis is a rare manifestation of myelofibrosis.
- Previous reports described cutaneous lesions as papules, nodules, or plaques.
Observation:
- A patient with myelofibrosis presented with bilateral leg ulcers.
- This clinical presentation is a novel manifestation of cutaneous extramedullary hematopoiesis.
- Histopathological examination of the ulcers revealed all three marrow elements (myeloid, erythroid, and megakaryocytes).
Findings:
- This case represents the first report of extramedullary hematopoiesis presenting as leg ulcers.
- The ulcers contained a tri-lineage hematopoietic infiltrate, distinct from previously reported cases.
- Cutaneous extramedullary hematopoiesis in myelofibrosis can present with diverse clinical manifestations.
Implications:
- Clinicians should consider extramedullary hematopoiesis in myelofibrosis patients with unexplained cutaneous lesions, including leg ulcers.
- Early recognition and diagnosis of cutaneous extramedullary hematopoiesis can guide appropriate management strategies.
- This case expands the spectrum of clinical presentations for extramedullary hematopoiesis in myelofibrosis.