Circadian rhythm in pineal methionine S-adenosyltransferase

The circadian rhythm of methionine S-adenosyltransferase, which catalyzes the formation of S-adenosylmethionine, a cosubstrate for melatonin in the pineal gland, follows the pattern of hydroxyindole-O-methyltransferase. Around the middle of the dark period, methionine S-adenosyltransferase and hydroxyindole-O-methyltransferase appear to be elevated by 2.5- and 1.5-fold, respectively, and tend to fall back during the light period.