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Effects of phenoxybenzamine on bladder neck opening
Journal of the Royal Society of Medicine
|May 1, 1980
Summary
Phenoxybenzamine effectively improves bladder neck opening during urination in men with prostatism symptoms. This alpha-blocker treatment increased opening by 30% and relieved symptoms with few side effects.
Area of Science:
- Urology
- Pharmacology
Background:
- Prostatism symptoms, often due to benign prostatic hyperplasia (BPH), can impede normal urination.
- Minimal prostatic enlargement presents a challenge for treatment selection.
Purpose of the Study:
- To investigate the efficacy of phenoxybenzamine in improving bladder neck opening during micturition.
- To assess the symptomatic relief provided by phenoxybenzamine in patients with prostatism and minimal prostatic enlargement.
Main Methods:
- Radiographic measurement of bladder neck opening.
- Administration of phenoxybenzamine to twenty patients with prostatism symptoms and minimal prostatic enlargement.
Main Results:
- Phenoxybenzamine demonstrated a significant increase in bladder neck opening, averaging 30%.
- Patients reported substantial symptomatic relief following treatment.
- The medication was associated with minimal adverse effects.
Conclusions:
- Phenoxybenzamine is an effective therapeutic option for enhancing bladder neck opening in patients with prostatism and minimal prostatic enlargement.
- The drug offers symptomatic improvement with a favorable side effect profile.