Related Experiment Videos
[Serotypes and drug-susceptibility of Streptococcus pneumoniae isolated from clinical specimens (author's transl)]
Abstract:
Serotypes and antibiotic susceptibility of Streptococcus pneumoniae from various clinical specimens from Jan. 1979 to July 1980 were examined. (1) The serotype of the organism widely distributed, and predominant serotypes were type 6, type 15, type 19, type 3 and type 23. Strains of type 2, 12 and 25, which were used as pneumococcal vaccine, were not found. (2) From the results of susceptibility test the most active drug was PCG among penicillins and CER among cephalosporins. There was one strain which was resistant to PCG and CER as well as CP and TC. Sixty-five% and 48% of the strains were resistant to TC and CP respectively. Almost of the strains were sensitive to macrolides and LCM. The occurrence of resistant strains to CP, TC, EM and LCM varied to the serotypes.
Insights
This study examined Streptococcus pneumoniae serotypes and antibiotic resistance in 1979-1980. Predominant serotypes were 6, 15, 19, 3, and 23, with no vaccine types found. Penicillin G and Cephalothin showed the most activity.
Area of Science:
- Microbiology
- Clinical Bacteriology
Context:
- Analysis of Streptococcus pneumoniae isolates from clinical specimens collected between January 1979 and July 1980.
- Focus on serotyping and antibiotic susceptibility patterns.
Purpose:
- To identify predominant serotypes of Streptococcus pneumoniae circulating during the study period.
- To determine the antibiotic susceptibility profiles of these isolates.
Summary:
- Predominant serotypes identified were 6, 15, 19, 3, and 23. Notably, vaccine serotypes 2, 12, and 25 were not detected.
- Penicillin G (PCG) and Cephalothin (CER) demonstrated the highest antimicrobial activity among tested drugs.
- High resistance rates were observed for Tetracycline (TC) (65%) and Chloramphenicol (CP) (48%).
- Most strains remained sensitive to macrolides and Lincomycin-Clindamycin (LCM).
- Serotype-specific variations in resistance to CP, TC, Erythromycin (EM), and LCM were noted.
Impact:
- Provides historical data on Streptococcus pneumoniae epidemiology and antimicrobial resistance.
- Informs antibiotic stewardship and vaccine development strategies.
- Highlights the importance of ongoing surveillance for emerging resistance patterns.