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Infantile polycystic renal disease in a rhesus monkey (Macaca mulatta)
Laboratory Animal Science
|April 1, 1981
Insights
Congenital infantile polycystic renal disease was diagnosed in an infant rhesus monkey, presenting enlarged kidneys with cystic tubules. This condition closely resembles the inherited infantile polycystic renal disease observed in humans.
Area of Science:
- Comparative pathology
- Primate models in disease research
- Renal and hepatic diseases
Background:
- Polycystic kidney disease (PKD) is a genetic disorder.
- Infantile PKD presents a severe early-onset form.
- Animal models are crucial for understanding human diseases.
Observation:
- A case study of an infant rhesus monkey diagnosed with congenital infantile polycystic renal disease.
- Gross and microscopic examination revealed enlarged kidneys with cystic tubules.
- Histological analysis showed biliary dysgenesis with increased, dilated intrahepatic bile ducts and fibrosis.
Findings:
- The rhesus monkey exhibited renal and hepatic abnormalities consistent with infantile polycystic renal disease.
- The observed pathology in the rhesus monkey mirrors key features of human infantile PKD.
- This case highlights the utility of non-human primates as models for studying genetic renal disorders.
Implications:
- This finding supports the use of rhesus monkeys as a valuable model for studying infantile polycystic renal disease.
- Understanding the pathogenesis in this model can inform therapeutic strategies for human PKD.
- Further research in primate models may elucidate genetic and molecular mechanisms underlying PKD.
Abstract:
Congenital infantile polycystic renal disease was diagnosed in the infant rhesus monkey. The kidneys were enlarged, and renal tubules were cystic. The intrahepatic bile ducts were increased in number, dilated, and surrounded by excessive fibrous tissue. This disease was similar to inherited infantile polycystic renal disease in man.