Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignant external otitis: early histopathologic changes and pathogenic mechanism

E Ostfeld, M Segal, B Czernobilsky

    The Laryngoscope
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Luteinized thecoma associated with sclerosing peritonitis--conservative surgical approach followed by corticosteroid and GnRH agonist treatment--a case report.

    Gynecologic oncology·2008
    Same author

    The Ki67+ proliferation index correlates with increased cellular retinol-binding protein-1 and the coordinated loss of plakophilin-1 and desmoplakin during progression of cervical squamous lesions.

    Histopathology·2007
    Same author

    Cellular retinol-binding protein-1 expression in endometrial stromal cells: physiopathological and diagnostic implications.

    Histopathology·2004
    Same author

    Nuclear localization of beta-catenin and plakoglobin in primary and metastatic human colonic carcinomas, colonic adenomas, and normal colon.

    International journal of surgical pathology·2003
    Same author

    Calcifying fibrous pseudotumor of mesentery presenting with acute peritonitis: case report with immunohistochemical study and review of literature.

    International journal of surgical pathology·2001
    Same author

    Alpha-smooth muscle actin-positive myofibroblasts in endometrial stroma are not a reliable criterion for the diagnosis of well differentiated endometrioid adenocarcinoma in small tissue samples.

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists·2001
    Same journal

    Superior Labial Artery Flap for Septal Perforation Repair: The Boxer's Flap.

    The Laryngoscope·2026
    Same journal

    3 French Suction Technique for Alignment of the OSIA Bone Conduction Hearing Implant: How I Do It.

    The Laryngoscope·2026
    Same journal

    Orticochea Flap for Reconstruction of Large Scalp Defects: Outcomes and Technique.

    The Laryngoscope·2026
    Same journal

    Rising Pediatric Button Battery Injuries Despite Safety Efforts: An Analysis of National Injury Data.

    The Laryngoscope·2026
    Same journal

    Laryngeal Nerve Protection Devices in Thyroid Surgery: A Systematic Review and Evidence Synthesis.

    The Laryngoscope·2026
    Same journal

    Practice Patterns for the Management of Pediatric oSDB: What Is the Current National Landscape?

    The Laryngoscope·2026
    See all related articles

    Malignant external otitis (MEO) involves opportunistic organisms invading devitalized tissue. Early MEO shows degenerated collagen predating microbial invasion, indicating compromised vasculature as the core disease mechanism.

    Area of Science:

    • Otolaryngology
    • Pathology
    • Infectious Diseases

    Background:

    • Malignant external otitis (MEO) is a severe infection of the external ear canal.
    • Understanding early histopathologic changes is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the early histopathologic features of malignant external otitis (MEO).
    • To elucidate the initial tissue changes preceding microbial invasion in MEO.

    Main Methods:

    • Histopathologic examination of diseased external ear canal tissue.
    • Specimens obtained via en bloc excision through a retroauricular approach in two MEO patients.

    Main Results:

    • Prominent finding: a thick, acellular, degenerated collagen layer in the dermis and cartilage.

    Related Experiment Videos

  • This collagen layer appears to predate the microorganism's penetration.
  • Suggests pre-existing tissue devitalization, likely from vascular compromise.

    • Conclusions:

    • MEO develops from opportunistic organisms invading previously devitalized tissue.
    • Vascular compromise is proposed as the fundamental mechanism underlying MEO.
    • Early collagen degeneration is a key indicator of pre-infection tissue compromise.