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Aminophylline improves diaphragmatic contractility

M Aubier, A De Troyer, M Sampson

    The New England Journal of Medicine
    |July 30, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    Aminophylline enhances diaphragmatic contractility and reduces diaphragm fatigue in healthy individuals. This medication improves the relationship between the diaphragm's electrical activity and the pressure it generates.

    Area of Science:

    • Respiratory Physiology
    • Pharmacology

    Background:

    • The clinical efficacy of aminophylline in respiratory conditions is well-established.
    • However, its precise mechanisms of action on respiratory muscles, particularly the diaphragm, require further elucidation.

    Purpose of the Study:

    • To investigate the effects of aminophylline on diaphragmatic contractility and fatigue resistance in healthy subjects.
    • To quantify the impact of aminophylline on the relationship between diaphragmatic electrical activity and generated pressure.

    Main Methods:

    • Assessed diaphragmatic electrical activity and pressure during voluntary contractions before and after aminophylline infusion.
    • Measured diaphragmatic pressure during phrenic nerve stimulation at various frequencies before and after induced fatigue, with and without aminophylline.

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    Main Results:

    • Aminophylline significantly increased the pressure generated by the diaphragm at a given electrical activity (15% increase, P < 0.001).
    • Aminophylline improved diaphragmatic pressure output following fatigue induction compared to baseline conditions without the drug.
    • The observed effects correlated with a mean plasma aminophylline concentration of 13 ± 0.9 mg/L.

    Conclusions:

    • Aminophylline enhances diaphragmatic contractility.
    • Aminophylline increases the diaphragm's resistance to fatigue.
    • These findings provide mechanistic insights into the clinical benefits of aminophylline in respiratory support.