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Related Experiment Videos

Hydroxyzine intoxication in a 13-month-old child

B E Magera, C J Betlach, A P Sweatt

    Pediatrics
    |February 1, 1981
    PubMed
    Summary

    Accidental hydroxyzine ingestion caused toxicity in an infant, presenting as seizures and tachycardia. Prompt supportive care and physostigmine led to full recovery, marking the first documented pediatric case of hydroxyzine toxicity.

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    Area of Science:

    • Pediatric Toxicology
    • Clinical Pharmacology
    • Emergency Medicine

    Background:

    • Hydroxyzine is a commonly prescribed antihistamine for allergic conditions.
    • Accidental overdose in pediatric patients can lead to significant adverse effects.
    • Understanding toxicity thresholds and management is crucial for safe pediatric prescribing.

    Observation:

    • A 13-month-old infant experienced hydroxyzine toxicity after accidental ingestion.
    • Clinical manifestations included generalized seizures and sinus tachycardia.
    • Elevated plasma hydroxyzine concentration of 102.7 µg/ml was recorded 8.5 hours post-ingestion.

    Findings:

    • Generalized seizures and sinus tachycardia were the primary signs of hydroxyzine toxicity.
    • Physostigmine was effective in controlling seizures.
    • Complete recovery was achieved within 72 hours with supportive care.

    Implications:

    • This case highlights the potential for severe toxicity from hydroxyzine overdose in young children.
    • Early recognition and prompt intervention, including the judicious use of physostigmine, are critical for favorable outcomes.
    • This report underscores the need for careful storage of medications to prevent accidental pediatric ingestion.

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