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Related Experiment Videos

Handy type haemofiltration-plasma exchange apparatus

O Otsubo, T Horiuchi, S Seo

    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
    |January 1, 1980
    PubMed
    Summary

    A portable machine for plasma exchange and hemofiltration was designed with a unique volume balancing mechanism. Evaluations showed acceptable fluid balancing, with favorable results in clinical tests, enabling decentralized treatment.

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    Area of Science:

    • Biomedical Engineering
    • Nephrology
    • Critical Care Medicine

    Background:

    • The need for accessible, portable medical devices for continuous renal replacement therapy (CRRT) and plasma exchange (PE) is increasing.
    • Existing CRRT and PE machines are often large, complex, and not suitable for decentralized or resource-limited settings.
    • A compact, lightweight, and user-friendly system is required to facilitate these life-saving treatments outside traditional intensive care units.

    Purpose of the Study:

    • To design and fabricate a novel, portable machine for plasma exchange and hemofiltration.
    • To incorporate a unique volume balancing mechanism for precise fluid management.
    • To evaluate the in vitro and in vivo performance of the portable device.

    Main Methods:

    • Design and fabrication of a compact and lightweight portable machine.

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  • Development and integration of a unique volume balancing mechanism.
  • In vitro and in vivo evaluation of fluid balancing accuracy and performance.
  • Clinical testing in a relevant patient population.

    • Main Results:

    • The designed portable machine demonstrated a simple, compact, and lightweight construction.
    • In vitro and in vivo evaluations yielded fully acceptable fluid balancing results.
    • Clinical tests were performed with favorable outcomes, indicating successful application.

    Conclusions:

    • The developed portable machine effectively performs plasma exchange and hemofiltration with a unique volume balancing system.
    • The device's design meets the requirements for portability and ease of use.
    • Favorable clinical results suggest the potential for wider application of decentralized CRRT and PE.