Decreased ethanol consumption as a function of pregnancy and lactation in C57BL mice

The effects of pregnancy and lactation on alcohol consumption were examined in the C57BL mouse. Pregnant mice were given a two-bottle choice between water and 10% w/v alcohol solution from Day 5 of pregnancy, through two weeks of lactation, and an additional four weeks following the removal of nursing pups. Alcohol consumption was expressed in terms of g absolute ethanol per kg body weight and as an alcohol preference ratio (ml alcohol/ml total fluid). Alcohol consumption (g ethanol per kg body weight) fell below control values during pregnancy and lactation but increased to control levels during postlactation. Similarly, alcohol preference ratio was found to decline during pregnancy, and to further decrease during lactation, a trend that was reversed during postlactation. The results support the findings of decreased alcohol consumption during pregnancy in alcoholic as well as nonalcoholic women.