Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hit probability for cellular targets by bone-surface-seeking alpha emitters

E Polig

    Physics in Medicine and Biology
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Surface-seeking radionuclides in the skeleton: current approach and recent developments in biokinetic modelling for humans and beagles.

    Radiation protection dosimetry·2007
    Same author

    Americium in the beagle dog: biokinetic and dosimetric model.

    Health physics·2006
    Same author

    Survival and bone tumor hazard from internal deposition of 226Ra in beagles.

    Health physics·2004
    Same author

    Biokinetic model of radium in humans and beagles.

    Health physics·2003
    Same author

    Uncertainty analysis of the urinary excretion of plutonium.

    Radiation protection dosimetry·2003
    Same author

    Modeling the distribution and dosimetry of internal emitters: a review of mathematical procedures using matrix methods.

    Health physics·2001

    This study models alpha-emitter irradiation near bone surfaces, finding hit probabilities correlate with dose rates. This impacts understanding radiation effects on bone cells and tumor development.

    Area of Science:

    • Radiological Physics
    • Biophysics
    • Oncology

    Background:

    • Surface-seeking alpha-emitters pose risks for bone irradiation.
    • Understanding cellular target irradiation near bone surfaces is crucial for dosimetry and risk assessment.

    Purpose of the Study:

    • To analyze hit probabilities for cellular targets near bone surfaces irradiated by alpha-emitters.
    • To develop a model correlating hit probability with dose rate distribution and spatial variations.

    Main Methods:

    • Geometrical factor analysis for hit probabilities to spherical targets.
    • Calculation of hit probability for non-uniform cell nucleus distribution on beagle bone surfaces.
    • Derivation of a general expression relating hit probability to dose rate distribution.

    Related Experiment Videos

    Main Results:

    • The geometrical factor is approximately proportional to dose rate over most of the particle range.
    • Numerical results were calculated using dose rate distributions from rat lumbar vertebrae.
    • Spatial variations in activity and burial depth were evaluated.

    Conclusions:

    • The study provides a framework for assessing radiation dose to bone cells from surface-deposited alpha-emitters.
    • Findings have implications for refining tumor models and radiation protection strategies near bone surfaces.