In vitro response of the regenerating adrenal gland to epinephrine

In this experiment, the adrenal medulla was removed from male rats and after 11 days, animals were sacrificed and the adrenal glands were incubated. Addition of epinephrine to the regenerating gland resulted in significant increase in corticosterone content in the gland. However, no significant changes were observed in the intact glands after epinephrine administration. The results of this experiment suggest that epinephrine may be playing a role in the adrenal cortex function.