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Increased lymphocyte adenosine deaminase in typhoid fever
Scandinavian Journal of Infectious Diseases
|January 1, 1981
Summary
Peripheral lymphocyte adenosine deaminase (L-ADA) activity was elevated in typhoid fever patients compared to controls. This increase persisted and may reflect the immune response to typhoid infection.
Area of Science:
- Immunology
- Biochemistry
- Infectious Diseases
Background:
- Typhoid fever is a significant global health concern.
- Understanding the host's immune response is crucial for managing typhoid.
Purpose of the Study:
- To investigate adenosine deaminase activity in peripheral lymphocytes (L-ADA) in patients with typhoid fever.
- To correlate L-ADA levels with the disease state and treatment.
Main Methods:
- Adenosine deaminase activity was measured in peripheral lymphocytes.
- Enzymatic activity was determined in 27 typhoid fever patients and 15 healthy controls.
Main Results:
- Significantly increased L-ADA activity was observed in typhoid fever patients compared to normal controls.
- Elevated L-ADA levels were prolonged and did not correlate with treatment status.
Conclusions:
- Increased L-ADA activity in typhoid fever suggests a role in the immune response.
- L-ADA levels may serve as a potential biomarker for typhoid fever.