Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Aminopenicillin: when, how, what kind?]

G Mombelli

    Schweizerische Medizinische Wochenschrift
    |May 2, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Aminopenicillins exhibit antibacterial activity against certain bacteria, but penicillin G is often preferred due to cost and fewer side effects. Oral amoxicillin and ampicillin esters offer better absorption and efficacy than ampicillin for lower dosages.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lipid-lowering therapy of everolimus-related severe hypertriglyceridaemia in a pancreatic neuroendocrine tumour (pNET).

    Journal of clinical pharmacy and therapeutics·2017
    Same author

    Individual dosage of digoxin in patients with heart failure.

    QJM : monthly journal of the Association of Physicians·2010
    Same author

    Mild cognitive impairment in medical inpatients: the Mini-Mental State Examination is a promising screening tool.

    Dementia and geriatric cognitive disorders·2010
    Same author

    Acute effect of smoking and of 2 weeks of folate substitution on hemostasis and homocysteine in healthy chronic smokers.

    Journal of thrombosis and haemostasis : JTH·2006
    Same author

    Variation in coagulation inhibitors during prolonged sitting: possible pathogenetic mechanisms for travel-associated thrombosis.

    Journal of thrombosis and haemostasis : JTH·2006
    Same author

    Venous stasis and thrombin generation.

    Journal of thrombosis and haemostasis : JTH·2004
    Same journal

    Respiratory function test in the case of temporary phrenic nerve contusion, associated with pneumoperitoneum; About the diagnostic value of laparoscopy.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Treatment of pulmonary tuberculosis and pleurisy by means of temporary paralysis of the diaphragm, supported by the pneumoperitoneum.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Boeck's disease as a tuberculous syndrome.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Enteral primary tubercular complexes

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Tuberculous stenoses of the large bronchi.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    About the enzyme action.

    Schweizerische medizinische Wochenschrift·2010
    See all related articles

    Area of Science:

    • Pharmacology
    • Microbiology
    • Infectious Diseases

    Context:

    • Aminopenicillins are a class of antibiotics with broad-spectrum activity.
    • Penicillin G serves as a benchmark antibiotic for comparison.
    • Understanding the comparative efficacy and safety of different penicillin derivatives is crucial for clinical decision-making.

    Purpose:

    • To compare the antibacterial activity, efficacy, and safety profiles of various aminopenicillins.
    • To evaluate the therapeutic advantages of amoxicillin, ampicillin esters, and epicillin against ampicillin and penicillin G.
    • To provide guidance on the appropriate use of penicillin derivatives in treating bacterial infections.

    Summary:

    • Aminopenicillins demonstrate similar antibacterial activity against penicillin-susceptible microorganisms and specific Gram-negative bacteria like E. coli, P. mirabilis, Salmonellae, Shigellae, and H. influenzae.

    Related Experiment Videos

  • Penicillin G is often favored over aminopenicillins due to its lower cost, higher activity, and reduced incidence of skin rashes.
  • For oral administration, amoxicillin and ampicillin esters (bacampicillin, pivampicillin) show superior absorption compared to ampicillin and epicillin, enabling lower effective dosages. Amoxicillin has extensive clinical data supporting its use.
  • Parenterally, amoxicillin and epicillin do not present significant therapeutic advantages over ampicillin, which remains the most extensively documented option.

    • Impact:

    • This comparison aids clinicians in selecting the most appropriate penicillin-based antibiotic for specific infections, optimizing treatment outcomes.
    • Highlights the cost-effectiveness and safety advantages of penicillin G in certain clinical scenarios.
    • Informs therapeutic strategies by identifying oral penicillin derivatives with improved pharmacokinetic profiles for enhanced patient compliance and reduced dosing frequency.