Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ethanol tolerance in the rat is learned

J R Wenger, T M Tiffany, C Bombardier

    Science (New York, N.Y.)
    |July 31, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Glucagon-like peptide 1 (GLP-1).

    Molecular metabolism·2019
    Same author

    Management of refractory lupus nephritis: challenges and solutions.

    Open access rheumatology : research and reviews·2019
    Same author

    Giri-nya-la-nha (talk together) to explore acceptability of targeted smoking cessation resources with Australian Aboriginal women.

    Public health·2018
    Same author

    Mastocytosis: a case series of 107 consecutive patients.

    The British journal of dermatology·2017
    Same author

    Regulation of food intake and body weight by insulin.

    Diabetologia·2016
    Same author

    Peptides and the control of meal size.

    Diabetologia·2016
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    Ethanol tolerance in rats requires practice during intoxication. Simply receiving ethanol doses after training does not induce tolerance. These findings challenge existing hypotheses on ethanol tolerance development.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Ethanol tolerance is a reduced response to alcohol after repeated exposure.
    • Previous research suggested repeated ethanol doses could induce tolerance.

    Purpose of the Study:

    • To investigate the conditions necessary for ethanol tolerance development in rats.
    • To challenge the hypothesis that repeated ethanol doses alone are sufficient for tolerance.

    Main Methods:

    • Rats were trained to walk on a treadmill to avoid foot shock.
    • One group practiced while intoxicated with ethanol.
    • A second group received ethanol after practice; controls received saline.

    Main Results:

    • Rats that practiced while intoxicated developed ethanol tolerance.

    Related Experiment Videos

  • Rats that received ethanol after practice did not develop tolerance.
  • Saline-treated controls also did not develop tolerance.

    • Conclusions:

    • Ethanol tolerance acquisition is dependent on performing the response during intoxication.
    • Mere repeated exposure to ethanol is insufficient to induce tolerance.
    • Context-dependent learning plays a crucial role in ethanol tolerance.