Peritoneal lavage with povidone-iodine solution in experimentally induced peritonitis

Area of Science:

• Veterinary Medicine
• Surgical Research
• Experimental Pathology

Background:

• Peritonitis is a serious abdominal condition requiring effective treatment.
• Povidone-iodine is an antiseptic solution sometimes used in medical procedures.

Purpose of the Study:

• To evaluate the efficacy and safety of peritoneal povidone-iodine lavage in a canine model of peritonitis.
• To investigate the impact of povidone-iodine lavage on bacterial counts, mortality, renal function, and acid-base balance.

Main Methods:

• Two experimental studies were conducted on dogs.
• Study 1: Induced peritonitis followed by peritoneal lavage with povidone-iodine or other regimens.
• Study 2: Performed peritoneal lavage with povidone-iodine on healthy dogs, comparing them to a sham laparotomy group.

Main Results:

• Povidone-iodine lavage was not superior to other regimens in reducing bacterial colony counts.
• A 100% mortality rate was observed in dogs with peritonitis treated with povidone-iodine.
• No adverse effects on renal function were noted.
• Significant metabolic acidosis (decreased base excess and serum bicarbonate) was induced by povidone-iodine lavage in both peritonitis and healthy dogs.

Conclusions:

• Peritoneal lavage with povidone-iodine is ineffective for treating peritonitis in this canine model.
• The solution is associated with high mortality and induces significant metabolic acidosis.
• Clinical use of povidone-iodine for peritoneal lavage in peritonitis is not recommended.