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Effects of saccharin on primary humoral antibody production in rats

W Luini, A Mantovani, S Garattini

    Toxicology Letters
    |April 1, 1981
    PubMed

    Abstract:

    Rats for 25 to 54 days with diets containing high concentrations (1;2.5; 5%) of saccharin showed marked, dose-dependent suppression of primary humoral antibody production against heterologous erythrocytes. Phytohemagglutinin (PHA)-induced blastogenesis was not consistently affected by these saccharin-containing diets.

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