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Updated: Oct 9, 2026

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Effects of saccharin on primary humoral antibody production in rats
Toxicology Letters
|April 1, 1981
Abstract:
Rats for 25 to 54 days with diets containing high concentrations (1;2.5; 5%) of saccharin showed marked, dose-dependent suppression of primary humoral antibody production against heterologous erythrocytes. Phytohemagglutinin (PHA)-induced blastogenesis was not consistently affected by these saccharin-containing diets.

