Thymic atrophy in mice induced by cadmium administration

The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show any change. Histopathologically, cortical atrophy of the thymus was very marked. The white pulp of the spleen tended to diminish in size any many polymorphonuclear leukocytes and myeloid cells appeared in the red pulp.