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Related Experiment Videos

Subacute sclerosing panencephalitis

M H Bellman, G Dick

    Postgraduate Medical Journal
    |September 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Subacute sclerosing panencephalitis (SSPE) is a rare neurological disorder caused by measles virus. This study reports on 96 UK cases, noting a 6.8-year delay from measles infection to SSPE onset.

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    Area of Science:

    • Neurology
    • Virology
    • Epidemiology

    Background:

    • Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disease.
    • SSPE is now understood to be caused by the measles virus.

    Purpose of the Study:

    • To report on cases of SSPE in the UK.
    • To analyze the epidemiology and clinical characteristics of SSPE.

    Main Methods:

    • Case registration in the UK since 1971.
    • Analysis of diagnostic criteria including clinical presentation, EEG, serology, and brain histology.
    • Review of patient demographics, disease onset, and survival times.

    Main Results:

    • Ninety-six SSPE cases were reported in the UK up to September 1977.

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  • The male to female ratio was 2:1.
  • The disease predominantly affected children aged 9-11, with an average delay of 6.8 years between measles infection and SSPE onset. Average survival post-diagnosis was 1.2 years for deceased patients.

    • Conclusions:

    • SSPE is a significant neurological complication of measles infection.
    • Further research is needed to understand the pathogenesis and epidemiology of SSPE.