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[Humoral and cellular immune responses to brain tissue in animals immunized with ADPT and smallpox vaccine]
Experiments on guinea-pigs showed that 3 subcutaneous injections of adsorbed DPT vaccine resulted (on days 7-14 of the experiment) in the accumulation of cells, sensitized to brain extract, in the lymphoid tissue. The production of circulating anticerebral autoantibodies occurred, as revealed by the indirect immunofluorescent method, during the whole time of the experiment (35 days). On days 28-35 of the experiment cellular immune reaction to autologous erythrocytes was detected in the peripheral blood of the immunized animals. The intracardiac injection of smallpox vaccine to the animals resulted in the appearance of lymphoid cells, sensitized to brain extract, on days 3-7 of the experiment, as well as in the appearance of anticerebral autoantibodies, detected by immunofluorescence, which circulated in the blood for 28 days. Cellular immune reaction to autologous erythrocytes in the peripheral blood of the guinea-pigs immunized with smallpox vaccine was registered on days 3-28 of the experiment.
Experiments on guinea-pigs showed that 3 subcutaneous injections of adsorbed DPT vaccine resulted (on days 7-14 of the experiment) in the accumulation of cells, sensitized to brain extract, in the lymphoid tissue. The production of circulating anticerebral autoantibodies occurred, as revealed by the indirect immunofluorescent method, during the whole time of the experiment (35 days). On days 28-35 of the experiment cellular immune reaction to autologous erythrocytes was detected in the peripheral blood of the immunized animals. The intracardiac injection of smallpox vaccine to the animals resulted in the appearance of lymphoid cells, sensitized to brain extract, on days 3-7 of the experiment, as well as in the appearance of anticerebral autoantibodies, detected by immunofluorescence, which circulated in the blood for 28 days. Cellular immune reaction to autologous erythrocytes in the peripheral blood of the guinea-pigs immunized with smallpox vaccine was registered on days 3-28 of the experiment.