Atypical epithelial proliferations in the fallopian tube

Between the years 1950 and 1979, thirty-nine diagnoses of "atypical epithelial proliferation in the fallopian tube" were made in the Gynecologic Pathology Laboratory at The Johns Hopkins Hospital. In this discussion, the criteria for histopathologic diagnosis of such alterations are described. This series demonstrated an association of the tubal proliferations with malignancy in the upper genital canal and exogenous or endogenous estrogen stimulation. However, progression of these proliferative conditions to invasive tubal cancer was not documented.