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Plasma carnitine in pregnancy

C Bargen-Lockner, P Hahn, B Wittmann

    American Journal of Obstetrics and Gynecology
    |June 15, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Pregnancy is associated with low carnitine levels in mothers, but fetuses have significantly higher concentrations of total carnitine, free carnitine, and acylcarnitine compared to their mothers.

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    Area of Science:

    • Biochemistry
    • Obstetrics
    • Perinatology

    Background:

    • Carnitine is essential for fatty acid metabolism.
    • Maternal and fetal carnitine levels during pregnancy are not well-characterized.

    Purpose of the Study:

    • To determine plasma levels of total carnitine, free carnitine, and acylcarnitine in pregnant women and their fetuses.
    • To investigate carnitine levels in specific pregnancy complications like essential hypertension and gestational diabetes.

    Main Methods:

    • Blood samples were collected from pregnant women (28-42 weeks gestation) and their fetuses.
    • Plasma concentrations of total carnitine, free carnitine, and acylcarnitine were measured.

    Main Results:

    • Pregnant women exhibited low levels of both total and free carnitine.

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  • Elevated total carnitine was observed in women with essential hypertension.
  • Acylcarnitine levels were decreased in gestational diabetics, potentially due to insulin treatment.
  • Fetal plasma levels of total carnitine, free carnitine, and acylcarnitine were significantly higher than maternal levels.

    • Conclusions:

    • Carnitine deficiency is common in late pregnancy.
    • Pregnancy complications like essential hypertension and gestational diabetes may alter carnitine metabolism.
    • Fetuses maintain higher carnitine levels than their mothers, suggesting active transport or differential metabolism.