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Temperature dependence of rat circadian pacemaker

F P Gibbs

    The American Journal of Physiology
    |July 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Hypothermia significantly delays the biological clock in blind female rats, with lower temperatures causing greater phase delays. This suggests impaired temperature compensation in their circadian rhythms.

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    Area of Science:

    • Chronobiology
    • Animal Physiology
    • Mammalian Circadian Rhythms

    Background:

    • Biological clocks are fundamental to organismal function.
    • Temperature significantly influences circadian rhythms in many species.
    • Rodents exhibit robust thermoregulation, potentially impacting their internal clocks.

    Purpose of the Study:

    • To investigate the impact of induced hypothermia on the circadian activity rhythms of blind female rats.
    • To quantify the relationship between core body temperature and phase shifts in rat circadian behavior.
    • To assess the temperature compensation of the biological clock in rats.

    Main Methods:

    • Blind female rats were housed in running-wheel cages under a controlled 12-h light-dark cycle.
    • Hypothermia was induced using ether anesthesia, ethanol wetting, and ice application.

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  • Colonic temperatures were maintained between 20-32°C for 3-16 hours in restraining cages.
  • Activity records were analyzed post-recovery to assess phase shifts.

    • Main Results:

    • Significant phase delays in activity rhythms were observed at temperatures below 28°C.
    • At 20°C, the biological clock ran at approximately 64% of normal speed.
    • A mean Q10 value of 1.33 was calculated, indicating altered temperature sensitivity.
    • These findings suggest a reduced capacity for precise temperature compensation.

    Conclusions:

    • Induced hypothermia causes significant phase delays in the circadian activity of blind female rats.
    • The rat's biological clock exhibits a Q10 of 1.33 under hypothermic conditions, higher than previously reported.
    • It is speculated that mature rats may have lost precise temperature compensation for their biological clock due to advanced thermoregulation.