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Published on: August 13, 2019
Menopausal estrogen therapy and hip fractures
Annals of Internal Medicine
|July 1, 1981
Summary
Menopausal estrogen therapy significantly reduced hip fracture risk in women under 80. Long-term oral estrogen use, especially in oophorectomized women, showed a protective effect against fractures.
Area of Science:
- Gerontology
- Epidemiology
- Women's Health
Background:
- Hip fractures are a significant health concern for older women.
- Menopausal hormone therapy has been investigated for various health effects.
Purpose of the Study:
- To investigate the association between menopausal estrogen therapy and hip fracture risk.
- To determine if estrogen therapy provides a protective effect against hip fractures in postmenopausal women.
Main Methods:
- A case-control study was conducted in a retirement community.
- Ninety-one hip fracture cases were compared to age- and race-matched controls.
- Estrogen use was assessed via medical records and interviews.
Main Results:
- Oral estrogen use exceeding 60 months was associated with a reduced risk of hip fracture (risk ratio = 0.42).
- This protective effect was more pronounced in oophorectomized women (risk ratio = 0.14).
- Fracture risk decreased with longer estrogen use duration but not with higher dosage.
Conclusions:
- Long-term menopausal estrogen therapy, particularly in oophorectomized women, may offer protection against hip fractures.
- Duration of estrogen use appears more critical than dosage for fracture risk reduction.
- Several other factors, including diabetes and corticosteroid use, were identified as independent risk factors for hip fracture.
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