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Pigmentary glaucoma: an ultrastructural study

C H Robinson, W Nopanitaya, S D McPherson

    Annals of Ophthalmology
    |January 1, 1981
    PubMed
    Summary
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    Pigmentary glaucoma is caused by pigment granules blocking the trabecular meshwork, not angle anomalies. Melanin granules may contain protein or lipids, contributing to this eye condition.

    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Glaucoma Research

    Background:

    • Pigmentary glaucoma is a form of secondary open-angle glaucoma.
    • It is characterized by the dispersion of pigment granules from the iris onto ocular structures.

    Observation:

    • Trabeculectomy tissue blocks from both eyes of a patient with pigmentary glaucoma were analyzed using light microscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM).
    • The examination focused on identifying structural anomalies in the anterior chamber angle and characterizing the nature of the pigment granules within the trabecular meshwork.

    Findings:

    • No evidence of developmental angle anomalies was found in the examined trabeculectomy samples.
    • The study identified a significant accumulation of pigment granules within the trabecular meshwork, strongly suggesting this as the cause of the observed glaucoma.

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  • Analysis indicated that these melanin granules are potentially rich in protein and/or unsaturated lipids.

    • Implications:

    • This research clarifies the etiology of pigmentary glaucoma, emphasizing pigmentary obstruction over anatomical abnormalities.
    • Understanding the composition of melanin granules may offer new targets for therapeutic interventions.
    • The findings contribute to the broader understanding of glaucoma pathogenesis and pigment dispersion syndrome.