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[Correlation of growth hormone and aetiology of psoriasis]
Insights
Psoriasis is linked to elevated levels of human growth hormone (STH). Increased STH correlates with the severity of skin lesions in psoriasis patients.
Area of Science:
- Dermatology
- Endocrinology
- Human Physiology
Background:
- Psoriasis exhibits pathological capillary alterations, accelerated epidermopoiesis, and increased metabolic activity.
- Psoriasis rarely manifests before the age of 20.
Purpose of the Study:
- To investigate the role of human growth hormone (STH) in the blood serum of psoriasis patients.
Main Methods:
- Serum STH levels were measured every 2 hours over a 24-hour period in 70 psoriasis patients and 40 healthy controls.
- Correlation between the extent of skin lesions and STH levels was analyzed.
Main Results:
- Average STH levels in psoriasis patients were found to be three times higher than in the control group.
- A positive correlation was observed between the extent of skin lesions and STH levels.
Conclusions:
- The findings suggest that elevated and persistent STH levels may play a causative role in psoriasis development.
- Psoriasis could be linked to a condition of persistent STH with variable individual penetrance.
Abstract:
Pathological alterations of capillaries, accelerated epidermopoesis, increased rate and extent of metabolism in the psoriatic lesion and first manifestation of psoriasis rarely in the first 20 years of life made us decide to investigate the human growth hormone (STH) in blood serum. In 70 patients suffering from psoriasis we found that the extention of skin lesions was correlated to the STH levels, which were determined every 2 h all over the day. The average STH level in psoriasis was three times as high as average value in the group of 40 controls. Thus, one can conclude that psoriasis is caused by a persistence of STH with individual penetrance.