Some triazole analogs as anti-inflammatory agents

4-[4-(3-Substituted-1-acetyloxycarbamido)-benzylidene] amino-1.2.4-triazoles were synthesized and evaluated for anti-inflammatory activity against carrageenin-induced foot paw edema in albino rats. All compounds, with the exception of one, afforded anti-inflammatory activity. Approximate LD50 of all the substituted triazoles was found to be higher than 750 mg/kg. Substitution at the phenyl group attached to N at the position 3 of the carbamide, in general, resulted in increase of anti-edema effect.