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[Acute renal failure and multiple trauma]

F Giacchino, A Aprato, A Vighetti

    Archivio Per Le Scienze Mediche
    |October 1, 1980
    PubMed
    Summary
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    Trauma can cause acute renal failure, often linked to shock and other factors damaging kidney tubules. This study examines different types and causes of acute kidney injury, reporting its mortality rates.

    Area of Science:

    • Nephrology
    • Pathophysiology
    • Trauma Medicine

    Context:

    • The relationship between trauma and acute renal failure (ARF) is increasingly understood.
    • Shock is a primary factor in tubulo-interstitial damage, often compounded by other etiological agents.
    • Understanding the diverse mechanisms of ARF is crucial for effective patient management.

    Purpose:

    • To analyze the etiopathogenesis of various acute renal failure patterns.
    • To investigate the role of shock and other contributing factors in renal damage.
    • To report the mortality rates of acute renal failure over a decade.

    Summary:

    • This review explores the pathophysiological basis linking trauma to acute renal failure.
    • It details how shock, toxic agents, immunologic, and coagulation mechanisms contribute to tubulo-interstitial damage and necrosis.

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  • The study categorizes ARF into functional, tubulo-interstitial, and cortical necrosis patterns, analyzing their origins.
  • Impact:

    • Provides a comprehensive overview of trauma-induced acute renal failure.
    • Highlights key etiological factors and patterns of kidney injury.
    • Offers historical mortality data for acute renal failure in a specific hospital cohort.