Related Experiment Video
Updated: Aug 16, 2026
10:10
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
Published on: October 27, 2009
The effect of platelet poor plasma serum on endothelial cell spreading
Artery
|January 1, 1981
Abstract:
In this study the effects of platelet poor plasma serum (PPPS) on the in-vitro spreading of trypsinized procine aortic endothelial cells (EC) was investigated. EC cultured in porcine PPPS spread more slowly on glass coverslips than did cells cultured in procine whole blodd serum (WBS). EC cultured in PPPS adhered to the glass as well as those in WBC and grew equally well in PPPS and in WBS. The results suggest that PPPS may be deficient in a substance which is necessary for prompt spreading of EC.
Related Concept Videos
01:17Intracellular Signaling Affects Focal Adhesions
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
01:22Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...