Severe meprobamate intoxication treated by hemoperfusion over amberlite resin

Related Experiment Video

Updated: Aug 18, 2026

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
11:25

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

L G Freund

    Artificial Organs
    |February 1, 1981
    PubMed

    More Related Videos

    Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma09:52

    Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

    Published on: January 25, 2015

    Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver09:02

    Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

    Published on: July 31, 2016

    Related Concept Videos

    Drug Elimination by Renal Route: Tubular Reabsorption01:22

    Drug Elimination by Renal Route: Tubular Reabsorption

    During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. However, the majority of drugs are either weak acids or weak bases, and their ionization level is dependent on pH. By altering the pH of urine, the...
    Enhanced Elimination of Poison01:26

    Enhanced Elimination of Poison

    Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
    Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
    Renal excretion is the...
    Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

    Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

    Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
    Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

    Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

    Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
    Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

    Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

    Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
    Hepatic Encephalopathy01:29

    Hepatic Encephalopathy

    DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...