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Severe meprobamate intoxication treated by hemoperfusion over amberlite resin
Artificial Organs
|February 1, 1981
Summary
Hemoperfusion using Amberlite XAD-4 resin effectively treated severe meprobamate intoxication. This method rapidly improved patient consciousness, demonstrating its high efficacy in overdose cases.
Area of Science:
- Toxicology
- Nephrology
- Materials Science
Background:
- Meprobamate overdose can lead to severe central nervous system depression.
- Hemoperfusion is a potential extracorporeal treatment for drug intoxication.
Observation:
- A 36-year-old female presented in deep coma after ingesting 40 gm of meprobamate.
- Hemoperfusion over Amberlite XAD-4 resin was initiated five hours post-ingestion.
Findings:
- The five-hour hemoperfusion treatment resulted in the patient regaining consciousness.
- Meprobamate clearance rate was approximately 290 mg/min with no observed bleeding complications.
Implications:
- Amberlite XAD-4 resin hemoperfusion is a highly effective treatment for severe meprobamate intoxication.
- This therapeutic approach offers a viable option for managing life-threatening drug overdoses.