Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solubilization of indometacin

H El-Sabbagh, A H Ghanem, H M Abdel-Alim

    Die Pharmazie
    |August 1, 1978
    PubMed
    Summary

    This study explored methods to increase the solubility of indometacin, an antirheumatic drug. Tween 80 and Brij 99 were most effective among non-ionic surfactants, while urea and sodium citrate also showed varied effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Iontophoretic transport of oligonucleotides across human epidermal membrane: a study of the Nernst-Planck model.

    Journal of pharmaceutical sciences·2001
    Same author

    Quantification of pore induction in human epidermal membrane during iontophoresis: the importance of background electrolyte selection.

    Journal of pharmaceutical sciences·2001
    Same author

    A neuromuscular test battery for osteoporotic women: a pilot study.

    American journal of physical medicine & rehabilitation·2001
    Same author

    Long-term home exercise program: effect in women at high risk of fracture.

    Archives of physical medicine and rehabilitation·2000
    Same author

    Mechanistic aspects of iontophoresis in human epidermal membrane.

    Journal of controlled release : official journal of the Controlled Release Society·1999
    Same author

    Pore charge distribution considerations in human epidermal membrane electroosmosis.

    Journal of pharmaceutical sciences·1999

    Area of Science:

    • Pharmaceutical Sciences
    • Drug Delivery
    • Physical Chemistry

    Background:

    • Indometacin is a widely used non-steroidal anti-inflammatory drug (NSAID) for rheumatic conditions.
    • Poor aqueous solubility can limit the bioavailability and therapeutic efficacy of indometacin.
    • Developing effective solubilization strategies is crucial for optimizing indometacin formulations.

    Purpose of the Study:

    • To investigate and compare three distinct methods for enhancing the aqueous solubility of indometacin.
    • To evaluate the efficacy of non-ionic surfactants, urea, and a urea-indometacin coprecipitate in solubilizing indometacin.
    • To understand the relationship between surfactant structure and solubilization efficiency.

    Main Methods:

    • Solubilization using non-ionic surfactants: Tween 80, Tween 40, Myrj 53, and Brij 99.
    • Solubilization using urea and sodium citrate at varying concentrations.
    • Preparation and solubility assessment of a urea-indometacin coprecipitate.

    Main Results:

    • Solubilization efficacy of non-ionic surfactants followed the order: Tween 80 and Brij 99 > Tween 40 > Myrj 53.
    • Solubilization efficiency decreased with increasing polyoxyethylene chain length in surfactants.
    • Urea enhanced indometacin solubility by improving solvation; sodium citrate increased solubility up to 0.2 M, then decreased it.
    • The urea-indometacin coprecipitate demonstrated a slight increase in drug solubility.

    Conclusions:

    • Non-ionic surfactants, particularly those with shorter polyoxyethylene chains like Tween 80 and Brij 99, are effective in solubilizing indometacin.
    • Urea and controlled concentrations of sodium citrate can also improve indometacin solubility.
    • The urea-indometacin coprecipitate offers a modest improvement in solubility, suggesting potential for formulation development.

    Related Experiment Videos