[Cimetidine in experimental gastric ulcers induced by pyloric ligation]

Male albino rats of the Wistar strain, without food from 48 h, have been operated with pylorus ligature and treated with cimetidine, at the dose of 30 mg/kg i.m., just after the operation and 12 h later. Cimetidine reduced the size and the number of gastric ulcers induced by pylorus ligature, showing a significant protective effect. This action, due to the inhibition of gastric secretion induced by cimetidine, supports the hypothesis that the staunching of gastric juice (by pylorus ligature) plays a basic role in the pathogenesis of these experimental gastric ulcers.