Related Experiment Videos
[Cimetidine and the hypothalamo-hypophysial-suprarenal axis]
Bollettino Della Societa Italiana Di Biologia Sperimentale
|January 15, 1981
Summary
Cimetidine did not alter stress responses in rats subjected to fasting and surgery. This study investigated cimetidine
Area of Science:
- Pharmacology
- Endocrinology
- Gastroenterology
Context:
- Experimental stress models are crucial for understanding physiological responses.
- The hypothalamo-hypophyseal-adrenal (HPA) axis plays a key role in stress.
- Cimetidine is a histamine H2 receptor antagonist.
Purpose:
- To investigate the effects of cimetidine on stress-induced physiological changes in rats.
- To determine if cimetidine interferes with the HPA axis during stress.
Summary:
- Male albino rats underwent stress via prolonged fasting and pylorus ligation.
- Cimetidine (30 mg/kg) was administered intramuscularly post-operation and 12 hours later.
- Adrenal ascorbic acid, cholesterol, and plasma corticosterone levels were measured.
Impact:
- Results suggest cimetidine does not modify stress-induced changes in this experimental model.
- Further research may be needed to explore cimetidine's role in stress management.