[Experimental basis fur using D-penicillamine in liver cirrhosis]

The therapeutic action of D-penicillamine (D-PA) in experimental liver cirrhosis was examined comprehensively and compared to that of prednisolone. D-RA primarily depressed fibrillogenesis, preventing the appearance of scar lesions in liver tissue. The drug exerted a beneficial effect on excretory and albumin-synthetizing function of the liver and had a protective action of oxidation function of liver mitochondria and the content of cytochromes. Unlike D-PA, prednisolone primarily reduced the manifestations of auto-immunization. The remainder of the tests have revealed no essential differences in the action of the drugs. The risk of prednisolone overdosage and side effects it produces have been recorded.