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Spontaneous gastric ulcers in a rhesus monkey
Brain Research Bulletin
|May 1, 1981
Summary
Spontaneous gastric ulcers are common in laboratory rhesus monkeys, potentially impacting research. These findings suggest naturally occurring models for human gastric ulceration research.
Area of Science:
- Veterinary Pathology
- Primate Medicine
- Gastroenterology
Background:
- Spontaneous gastric ulcers and erosions were observed in an adult male rhesus monkey.
- Clinical signs included weight loss, anorexia, and anemia.
Purpose of the Study:
- To report spontaneous gastric ulceration in a laboratory rhesus monkey.
- To discuss the implications for experimental research and potential use as a model for human gastric ulceration.
Main Methods:
- Necropsy findings of gastric ulcers and erosions.
- Review of antemortem clinical data including weight, appetite, and bloodwork.
Main Results:
- Confirmation of spontaneous gastric ulcers and erosions at necropsy.
- Antemortem signs of progressive weight loss, anorexia, and microcytic, hypochromic anemia.
Conclusions:
- Spontaneous gastric ulceration may be common in nonhuman primates in laboratory settings.
- Experimental induction of gastric ulcers in rhesus monkeys may be confounded by spontaneous lesions.
- These animals could serve as valuable naturally occurring models for human gastric ulceration studies.