Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional and structural changes in the rabbit ear artery after sympathetic denervation

R D Bevan, H Tsuru

    Circulation Research
    |August 1, 1981
    PubMed
    Summary

    Nerve removal in rabbit ear arteries impacts their development and function. Denervation reduced artery size and contractility, while increasing elasticity and norepinephrine sensitivity, with effects varying by age.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Somatic mosaicism for a SLC2A1 mutation: implications for genetic counseling for GLUT1 deficiency syndrome.

    Clinical genetics·2017
    Same author

    Absence of endothelium in invertebrate blood vessels: significance of endothelium and sympathetic nerve/medial smooth muscle in the vertebrate vascular system.

    Japanese journal of pharmacology·2002
    Same author

    Dimensions and wall force development capacity of human pial arteries from normotensives is not altered in obesity.

    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity·2001
    Same author

    Effect of JTH-601, a putative alpha(1L)-adrenoceptor antagonist, on guinea pig nasal mucosa vasculature.

    European journal of pharmacology·2001
    Same author

    Effect of hydrogen peroxide on guinea pig nasal mucosa vasculature.

    Japanese journal of pharmacology·2001
    Same author

    Potentiation of stretch-induced tone in the rabbit facial vein by an isoquinoline derivative, LOE 908.

    Naunyn-Schmiedeberg's archives of pharmacology·2001

    Area of Science:

    • Vascular biology
    • Neuroscience
    • Developmental biology

    Background:

    • The central ear arteries of rabbits are crucial for regulating blood flow.
    • Innervation plays a role in the development and maintenance of vascular structures.
    • The impact of denervation on arterial properties can vary with age.

    Purpose of the Study:

    • To investigate the effects of denervation on the physical and functional properties of rabbit central ear arteries.
    • To determine how age influences the consequences of denervation on arterial development and maintenance.

    Main Methods:

    • Superior cervical ganglionectomy was performed on rabbits at three different age groups: growing (3-4 weeks), young adult (9-11 weeks), and mature (16-20 weeks).
    • Tissue weight, dimensions, contractility, elasticity, and sensitivity to norepinephrine (NE) were measured in denervated and innervated artery segments 8 weeks post-surgery.

    Related Experiment Videos

  • Comparisons were made between denervated and contralateral control vessels within each age group.

    • Main Results:

    • In growing rabbits, denervation led to significant decreases in tissue weight, wall thickness, medial cross-sectional area, and contractility.
    • Denervation also resulted in increased tangential modulus of elasticity and a 2.3-fold increase in sensitivity to norepinephrine in growing rabbits.
    • Medial cross-sectional area changes were significant in growing and young adult rabbits, but not in mature rabbits, indicating age-dependent effects.

    Conclusions:

    • Intact innervation is essential for the normal development and maintenance of the artery wall.
    • The specific effects of innervation on arterial properties are age-dependent.
    • The underlying mechanisms, potentially involving trophic factors, require further investigation.