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Related Experiment Videos

Inhalation challenge in humidifier fever

J H Edwards, A Cockcroft

    Clinical Allergy
    |May 1, 1981
    PubMed
    Summary

    Exposure to contaminated humidifier water caused humidifier fever in most subjects, indicating an immune response. This study investigated the immunological mechanisms behind humidifier fever symptoms.

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    Area of Science:

    • Environmental Health
    • Immunology
    • Occupational Medicine

    Background:

    • Humidifier fever is a hypersensitivity pneumonitis.
    • The exact cause and immune mechanisms are not fully understood.

    Purpose of the Study:

    • To investigate the immunological basis of humidifier fever.
    • To determine if humidifier fever is mediated by endotoxins or an immune response.

    Main Methods:

    • Subjects were exposed to contaminated humidifier water.
    • Lung function, temperature, and leukocyte counts were monitored.
    • Rabbits were inoculated with humidifier water to test for pyrogenic activity.
    • Skin testing was performed on subjects.

    Main Results:

    • Four out of six exposed subjects developed humidifier fever symptoms.
    • Immune response, not endotoxin activity, was implicated.
    • Skin tests showed immediate reactions in subjects with precipitins.

    Conclusions:

    • Humidifier fever is likely an immunologically mediated disease.
    • The immune response may involve short-term anaphylactic IgG antibodies.
    • Further research is needed to fully characterize the immune response.

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