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Related Experiment Videos

Plasma lysozyme level and reticuloendothelial system function in human liver disease

A C van Vliet, W H Bakker, J Lindemans

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |June 18, 1981
    PubMed
    Summary

    Plasma lysozyme levels indicate reticuloendothelial system (RES) function. In acute hepatitis, lower lysozyme and RES function improved with recovery, suggesting RES activity influences lysozyme levels in liver disease.

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    Area of Science:

    • Hepatology
    • Immunology
    • Reticuloendothelial System (RES) Function

    Background:

    • Plasma lysozyme levels are considered indicators of reticuloendothelial system (RES) functional status.
    • Understanding RES function is crucial for managing liver diseases like hepatitis and cirrhosis.

    Purpose of the Study:

    • To investigate the relationship between plasma lysozyme levels and RES function in patients with acute hepatitis and cirrhosis.
    • To assess how changes in liver disease severity impact plasma lysozyme and RES function.

    Main Methods:

    • Measured plasma lysozyme levels in patients with acute hepatitis and cirrhosis.
    • Assessed RES function by determining the disappearance rate (t/2) of radio-labelled sulphur colloid in a subset of patients.
    • Compared findings with healthy controls.

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    Main Results:

    • Patients with acute hepatitis exhibited significantly lower plasma lysozyme levels and colloid t/2 compared to healthy controls and cirrhotics.
    • In acute hepatitis patients, plasma lysozyme levels increased as the condition improved.
    • A significant positive correlation was observed between plasma lysozyme levels and colloid t/2 in patients with liver disease (r = +0.66, p = 0.005).

    Conclusions:

    • Plasma lysozyme levels reflect RES functional status in human liver disease.
    • Increased RES activity is associated with lower plasma lysozyme levels in liver disease.
    • These findings offer insights into the pathophysiology of liver diseases and potential biomarkers for RES function.