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Hematologic studies during isolated ultrafiltration

T S Ing, W T Chen, D V Weber

    Clinical Nephrology
    |June 1, 1981
    PubMed
    Summary
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    Isolated ultrafiltration in hemodialysis causes a temporary drop in leucocytes and platelets but does not significantly affect clotting factors or cause hemolysis. These hematologic changes are consistent with standard hemodialysis procedures.

    Area of Science:

    • Nephrology
    • Hematology
    • Biochemistry

    Background:

    • Maintenance hemodialysis patients undergo ultrafiltration to remove excess fluid.
    • The impact of isolated ultrafiltration on blood components requires detailed evaluation.

    Purpose of the Study:

    • To assess the acute effects of negative-pressure isolated ultrafiltration on leucocytes, platelets, and clotting factors in hemodialysis patients.
    • To determine if isolated ultrafiltration causes hemolysis or significantly alters the coagulation system.

    Main Methods:

    • Evaluated changes in leucocyte and platelet counts during and after isolated ultrafiltration.
    • Measured levels of haptoglobin, free hemoglobin, fibrinogen, fibrin degradation products, and fibrin monomers.
    • Compared these values to pre-ultrafiltration levels and assessed the effect of heparin.

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    Main Results:

    • A transient decrease in leucocyte count was observed within the first 45 minutes, returning to baseline by one hour.
    • A modest decrease in platelet count was noted, with no significant changes in haptoglobin, free hemoglobin, fibrinogen, or fibrin degradation products.
    • Heparin administration alone did not affect the measured hematologic parameters.

    Conclusions:

    • Isolated ultrafiltration, as performed in clinical practice, has minimal acute effects on the coagulation system.
    • The procedure does not cause detectable hemolysis.
    • Transient leucocyte and modest platelet count reductions are consistent with known hemodialysis-induced changes.