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Ketoprofen-aspirin interactions

R L Williams, R A Upton, J N Buskin

    Clinical Pharmacology and Therapeutics
    |August 1, 1981
    PubMed
    Summary
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    Concurrent use of aspirin and ketoprofen in healthy men revealed a complex drug interaction. Aspirin significantly altered ketoprofen

    Area of Science:

    • Pharmacology
    • Drug Metabolism
    • Clinical Pharmacology

    Background:

    • Ketoprofen and aspirin are commonly co-administered nonsteroidal anti-inflammatory drugs (NSAIDs).
    • Understanding potential drug-drug interactions between these NSAIDs is crucial for patient safety.

    Purpose of the Study:

    • To investigate the pharmacokinetic interaction between ketoprofen and aspirin when administered concurrently.
    • To determine how aspirin affects the absorption, disposition, and metabolism of ketoprofen.

    Main Methods:

    • Healthy male subjects received both ketoprofen and aspirin orally to steady-state levels.
    • Plasma concentrations and protein binding of ketoprofen were monitored.
    • Salicylate and ketoprofen metabolites were analyzed in plasma and urine.

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    Main Results:

    • Aspirin did not affect the absorption or disposition of salicylate.
    • Concurrent aspirin administration decreased ketoprofen protein binding and increased its plasma clearance.
    • Salicylate appeared to reduce the metabolic conversion of ketoprofen to conjugates and their renal elimination.

    Conclusions:

    • The drug-drug interaction between aspirin and ketoprofen is complex and involves multiple pharmacokinetic pathways.
    • Concurrent use of these NSAIDs can alter ketoprofen metabolism and elimination, potentially impacting efficacy and safety.