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Related Experiment Videos

Leucocyte ATP and renal failure

M A Mansell, A J Grimes, N F Jones

    Clinical Science (London, England : 1979)
    |July 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Leukocyte adenosine 5'-triphosphate (ATP) levels are reduced in patients with renal failure. This finding contrasts with elevated erythrocyte ATP in uremia and may relate to cell function abnormalities.

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    Area of Science:

    • Biochemistry
    • Nephrology
    • Hematology

    Background:

    • Renal failure (uremia) is associated with various cellular dysfunctions.
    • Erythrocyte adenosine 5 '-triphosphate (ATP) levels are known to be elevated in uremic patients.

    Purpose of the Study:

    • To measure adenosine 5 '-triphosphate (ATP) levels in leukocytes from patients with renal failure.
    • To compare leukocyte ATP levels with erythrocyte ATP levels in uremia.
    • To discuss the implications of altered leukocyte ATP in uremic cell function.

    Main Methods:

    • Isolation of leukocyte suspensions from patients with renal failure.
    • Measurement of adenosine 5 '-triphosphate (ATP) levels in these isolated leukocytes.

    Main Results:

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    • Leukocyte adenosine 5 '-triphosphate (ATP) levels were found to be reduced in patients with renal failure.
    • This reduction in leukocyte ATP contrasts with the previously observed elevation in erythrocyte ATP in uremia.

    Conclusions:

    • Reduced leukocyte ATP in renal failure may contribute to observed abnormalities in cation transport.
    • The findings suggest a potential link between leukocyte ATP depletion and impaired cell function in uremia.