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Left ventricular volumetry and function in chronic cor pulmonale

V Jezek

    Cor Et Vasa
    |January 1, 1981
    PubMed
    Summary

    Chronic obstructive bronchopulmonary disease does not cause left ventricular contractile insufficiency. However, some patients exhibit abnormal heart pressures, impacting systolic performance despite normal ejection fraction.

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    Area of Science:

    • Cardiology
    • Pulmonology
    • Cardiovascular Physiology

    Background:

    • Chronic cor pulmonale, often linked to chronic obstructive bronchopulmonary disease (COPD), can affect cardiovascular function.
    • The precise impact of COPD on left ventricular (LV) function, particularly in the absence of other cardiovascular diseases, requires further elucidation.

    Purpose of the Study:

    • To investigate left ventricular (LV) structure and function in patients with chronic cor pulmonale, excluding other cardiovascular conditions.
    • To determine the relationship between pulmonary hypertension and observed LV abnormalities.

    Main Methods:

    • Cardiac catheterization and coronary arteriography were performed on 19 patients with chronic cor pulmonale.
    • Assessment included evaluation of LV hypertrophy, filling pressures, compliance, and ejection fraction.

    Main Results:

    • A subset of patients displayed left ventricular hypertrophy, elevated filling pressures, and reduced compliance.
    • Left ventricular ejection fraction remained normal and did not correlate with elevated filling pressures.
    • These LV abnormalities correlated with the degree of pulmonary hypertension and LV hypertrophy with reduced compliance.

    Conclusions:

    • Chronic obstructive bronchopulmonary disease does not lead to left ventricular contractile insufficiency at rest.
    • In some patients, normal systolic performance is maintained under abnormal hemodynamic conditions, specifically elevated LV filling pressures.
    • The findings suggest that pulmonary hypertension in COPD can induce significant left ventricular diastolic dysfunction.

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