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Lymphocyte reactivity in Imuran-treated guinea-pigs and in vitro effect of colchicine

D Milosević, I Sami, N Stanojević-Bakić

    Experientia
    |May 15, 1981
    PubMed

    Imuran treatment significantly diminished macrophage migration inhibition in immunized guinea-pigs and the percentage of E-rosette forming cells in all treated animals. 10(-6) M colchicine in vitro significantly increased the percentage of E-rosette forming cells in Imuran-treated animals. The results suggest possible alteration of the lymphocyte receptors after treatment with Imuran.

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