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Interval computed tomography in multiple sclerosis

M A Weinstein, R J Lederman, A D Rothner

    Radiology
    |December 1, 1978
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    Computed tomography reveals white matter changes in multiple sclerosis (MS) patients. Acute MS lesions show specific attenuation patterns on scans, evolving over time.

    Area of Science:

    • Radiology
    • Neurology
    • Medical Imaging

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • White matter lesions are a hallmark of MS pathology.
    • Computed tomography (CT) is a key imaging modality for neurological assessment.

    Observation:

    • CT scans identified abnormal white matter attenuation in 14 multiple sclerosis patients.
    • Nine patients underwent serial CT examinations, allowing for longitudinal observation.
    • Acute MS lesions displayed distinct attenuation characteristics, with and without contrast enhancement.

    Findings:

    • Acute lesions showed decreased or normal attenuation without contrast and increased attenuation with contrast.
    • Subsequent scans revealed decreased attenuation in these lesions, irrespective of contrast.

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  • Lesion attenuation evolved over time, with some persisting as decreased and others normalizing.

    • Implications:

    • CT findings provide insights into the dynamic nature of MS lesions.
    • Understanding lesion evolution aids in monitoring disease progression.
    • CT imaging can help differentiate acute from chronic changes in MS.