Sensitivity to endogenous progesterone. Report of a case

Area of Science:

• Dermatology
• Immunology
• Endocrinology

Background:

• Cyclic premenstrual eruptions are uncommon dermatological conditions.
• Autoimmune reactions to endogenous hormones are a potential, though rarely diagnosed, cause.
• Progesterone hypersensitivity can manifest in various clinical presentations.

Observation:

• A case report details a patient with cyclic eruptions preceding menstrual flow.
• The eruption resolved spontaneously with menstruation.
• Diagnostic tests confirmed hypersensitivity to endogenous progesterone.

Findings:

• Intradermal tests and leukocyte migration inhibition tests were positive for progesterone hypersensitivity.
• Treatment with conjugated estrogens resulted in complete remission of the premenstrual eruptions.
• This suggests an autoimmune basis for the patient's condition.

Implications:

• Highlights the importance of considering progesterone autoimmune mechanisms in cyclic dermatoses.
• Suggests conjugated estrogens as a potential therapeutic option for such cases.
• Emphasizes the need for increased clinical awareness of hormone-related autoimmune skin conditions.