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Acquired chloride diarrhea

B S Kaplan, B Vitullo

The Journal of Pediatrics

|August 1, 1981

Summary

Seven patients experienced intractable diarrhea with significant chloride loss, leading to metabolic alkalosis and electrolyte imbalances. This acquired condition, termed chloride diarrhea, may be sustained by ongoing fecal chloride excretion.

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Area of Science:

Gastroenterology
Nephrology
Clinical Medicine

Background:

Intractable diarrhea presents a diagnostic challenge.
Electrolyte disturbances are common complications of severe diarrheal diseases.

Purpose of the Study:

To investigate the underlying mechanisms in patients with intractable diarrhea and specific electrolyte abnormalities.

Main Methods:

Clinical case observation of seven patients.
Analysis of stool and urine electrolytes.
Assessment of acid-base and electrolyte status.

Main Results:

Patients exhibited high fecal chloride excretion.
Metabolic alkalosis, hyponatremia, hypokalemia, and hypochloremia were observed.
Urine chloride levels were notably low, indicating renal chloride conservation.

Conclusions:

Identified an acquired, transient form of chloride diarrhea.
Fecal chloride loss is implicated as a perpetuating factor in this condition.