Glucose tolerance curves in genetically diabetic KK-CAy mice: the pharmacokinetic analysis for humping effect

Pharmacokinetic analysis on glucose tolerance curves in genetically diabetic KK-CAy mice treated with hypoglycemics was investigated using an analog computer. The glucose tolerance curves in KK-CAy mice showed humping phenomena. They could not be simulated by a simple compartmental model, but might be fitted to the model containing the non-linear function. "Compartment-H" model was contrived by adding the H-factor between glucose and insulin compartments. All the glucose tolerance curves in the KK-CAy mice could be simulated reasonable by this model and some suggestions on the humping effect were obtained from the analysis of H-factor. The H-factor was observed to be influenced by adrenergic alpha-blocker. This pharmacokinetic approach was indicated to be useful for the pharmacological research.