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Related Experiment Videos

Cryptococcal meningitis in pregnancy

D N Curole

    The Journal of Reproductive Medicine
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Two cases of cryptococcal meningitis in pregnancy were successfully treated. Pregnant patients received amphotericin B or a combination of amphotericin B and flucytosine, resulting in good outcomes for both mother and fetus.

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    Area of Science:

    • Obstetrics and Gynecology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Cryptococcal meningitis is a serious fungal infection that can occur during pregnancy.
    • Treatment decisions during pregnancy require careful consideration of maternal and fetal safety.
    • Limited data exists on the safety and efficacy of antifungal therapies in pregnant patients.

    Observation:

    • Two pregnant patients diagnosed with cryptococcal meningitis were identified.
    • Case 1: received amphotericin B in the first trimester.
    • Case 2: received a combination of amphotericin B and flucytosine (5-fluorocytosine) in the second trimester.

    Findings:

    • Both pregnant patients completed their antifungal therapy.
    • Both cases demonstrated favorable fetal and maternal outcomes.

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  • No adverse effects were reported in either the mothers or the neonates.

    • Implications:

    • Combined antifungal therapy, including amphotericin B and flucytosine, appears safe and effective for treating cryptococcal meningitis during pregnancy.
    • These findings support the use of established antifungal agents in managing serious infections in pregnant individuals.
    • Further research is warranted to establish definitive treatment guidelines for cryptococcal infections in pregnancy.